The grid-search method is simple, fast and can quickly determine a rough solution. Taking the advantages of these two methods, the authors put forward the grid-search and genetic algorithm joint inversion under solution-domain constraints for microseismic events. The authors discuss the forward modeling, the first arrival sensitivity and perforation information closely related to the inversion calculation. Applications of this method in both synthetic datasets and real datasets prove that the accuracy, the efficiency and the stability are obviously improved by the joint inversion method than the search inversion or the genetic algorithm inversion only.