Based on well data and seismic data, the Zhuhai and Enping formations in the Huizhou Depression of the Pearl River Mouth Basin are divided into short-term, middle-term, and long-term base-level cycles. The structure of the short-term base-level cycles could be subdivided into asymmetric upward-deepening, asymmetric upward-shallowing and symmetric basic structure types. The base-level cycles of different orders are correlated using seismic data and method of cycle isochrostratigraphy correlation. Isochronous stratigraphic frameworks are established and used in the correlation of sand- bodies. Finally, the distribution and evolution of deep reservoirs are analyzed within isochronous stratigraphic frameworks.