Quartz-diorite intrusion is spatially and temporally associated with the REE-Sc mineralization in the Yijiang REE-Sc deposit, Rucheng County, Hunan Province. To constrain the age of the quartz-dioritic pluton related to REE-Sc mineralization, the authors conducted U-Pb analysis of zircon. Hafnium isotope data were also acquired through laser-ablation multi-collector ICPMS analysis of the zircon. Hafnium analysis shows that the Caledonian quartzdiorite has negative and variable εHf values (-1.9 to -7.6) and Palaeo-Mesoproterozoic (1.5 to 1.9 Ga) depleted-mantle model ages, which is interpreted to reflect derivation from an isotopically heterogeneous mantlecrust mixed source.