Douzhashan granite is an important uranium-bearing granite in Miaoershan uranium ore field, northeastern Guangxi. Based on mineralogical study, chlorites can be classified as two types: ripidolite and diabantite, and the alteration of U-rich accessory minerals is closely correlated to the ripidolite which formed in higher temperature.  The hydrothermal alteration not only made the uranium liberated from the altered accessory minerals into fluid, but also changed the occurrence of thorite-coffinite from included in xenotime to secondary apatite. So, uraninite, altered monazite and xenotime, thorite-coffinite included in secondary apatite are uranium resource minerals in Douzhashan uranium-bearing granite.