Based on seismic micro-zoning, probabilistic earthquake and extensive collection of the data of seismic geology, earthquake disaster prediction and countermeasure researches have been carried out within 89. 3 km2 in the urban area of Dongguan City, so that the analysis of earthquake damage on buildings (structure) and lifeline engineering under various intensity, the estimation of the affect caused by earthquake-induced disasters, and casualties and economic losses have been made out; the earthquake resistant capacity of the working area and Dongguan has been assessed comprehensively; earthquake disaster defending countermeasures have been proposed; and the GIS-based information management of earthquake prevention and disaster reduction and emergency response decision-making support system, information service system of earthquake prevention and disaster reduction and 3D visualization modules aboveground and underground have been developed.