In this paper, an Agilent 7500a ICP-MS coupled with a Resonetics RESOlution M-50 laser-ablation system was used to analyze 37 trace elements for 7 MPI-DING glass standards. RESOlution M-50 laser-ablation system consists of an excimer (193 nm) laser, a two-volume laser-ablation cell, a Squid smoothing device and a computer controlled high precision X-Y stage. The two-volume laser-ablation cell is designed to avoid cross contamination and reduce background flushing time. The Squid smoothing device can reduce statistic error induced by laser-ablation pulses. The accuracy of the X-Y stage is better than 0. 1 μm. The relative standard deviations (RSDs) are mostly less than 5%, and relative deviations (RDs) of obtained average concentrations from reference values are mostly less than 10%, only a few elements have high RSD due to very low concentrations and/or heterogeneities.