Block Sagizski (Block S) is located in the Southeast of Pre-Caspian Basin. The authors aim at the salt layer characteristics and its effect on hydrocarbon accumulation by means of geological analysis, seismic interpretation and typical oil/gas pool dissection. Based on studies, the characteristics of the salt thereby are described. The effects of salt on the hydrocarbon accumulation within post-salt strata (including the strata over and between salt domes)  in Block S can be concluded as follows: trap types and its distribution of the post-salt strata are well controlled by the salt. The scale of salty window influences the accumulation degree of oil pool nearby.