Ailaoshan gold belt, one of the most important Himalayan orogenic-type gold belt in China, formed during the processes of superimposed orogenesis in Sanjiang Tethys. The relationship between mineralization events and tectono-thermochronology as well as the related geodynamic regimes has been discussed in terms of the isotope dating result of gold mineralization in Ailaoshan orogenic belt. The metallogenic characteristics, combined with published geological and isotopic information, indicate that the large-scale gold metallogeny is closely related to the intense crust-mantle material exchange and the tectonic deformation in the transition of geodynamic regimes.