In this paper, lithium isotope geochemistry was used to study ore-bearing Wandongshan intrusion and ore-barren Jianchuanbei intrusion in Jinshajiang-Honghe alkaline-rich intrusive belt. The results show that the Li/Yb ratio ranges of Wandongshan intrusion and Jianchuanbei intrusion are 7.20~9.58 and 11.18~20.0, respectively.δ7Li values of Wandongshan intrusion and Jianchuanbei intrusion are +0.3‰~+6.2‰ and -6.5‰~+0.1‰, respectively. This result may due to the different degrees of slab-derived fluid metasomatism between ore-bearing Wandongshan intrusion and ore-barren Jianchuanbei intrusion.bidi-font-size: 12.0pt">