In view of relations between paleogeomorphology, sedimentary facies and seismic attributes, this paper presents multi-attribute cluster analysis method and demonstrates its rationality under constraining condition of paleogeomorphology. The optimized seismic attributes followed by cluster analysis can be applied to prediction of reef reservoir and fluid property. The case study from Sichuan Basin shows that such a multi-attribute cluster analysis method can effectively characterize the favorable facies, physical features and partial fluid characteristics of reef reservoir.