Tongling ore cluster region is one of the most important non-ferrous metal producers. Petrology, mineralogy and element geochemistry of these Mesozoic intrusive rocks in the Tongling region were investigated. The results show that: the intrusive rocks can be divided into three rock associations: pyroxene diorite with SiO2≤55%, quartz diorite with SiO2 55%~65%, and granodiorite associations with SiO2≥65%; 2) pyroxene diorite association rocks are mainly with characteristics of shoshonite; 3) quartz diorite and granodiorite association rocks are mainly composed of high potassic calc-alkaline; and 4) the Early Cretaceous period magmatic activity and related metallogenesis are closely related to the Pacific plate subduction.