The Anqing copper-iron deposit is a typical skarn-type deposit, which is located in the Anqing-Guichi ore cluster along the Middle and Lower Yangtze River Cu (Au)-Fe metallogenic belt. Analyses of the typical skarn samples systematically collected from a cross section show that the ore bodies and surrounding rocks have a significant petrochemical zoning with variation of mineral assemblage in space. The results of regional magmatic process indicate a complex origin of the Anqing copper-iron deposit by ore pulp penetration with contact metasomatism. Fe-riched ore pulp formed by immiscibility in shallow magma chamber should be the main source of ore-forming elements in the deposit.