lang=EN-US>Based on the previous studies, this paper introduces the researches on biogeochemical processes and nutrient cycling occurring mainly at rock/soil and soil/plant interfaces in karstic ecological system by using chemical balance theory, stoichiometry and multiple isotope tracers (e.g., δ13C, δ15N, δ34S, 87Sr/86Sr). The achieved important understandings are that the biogeochemical cycling of nutrients in karstic ecological system is active, coupled to each other and closely related to eco-environmental change, that human activities are clearly impacting natural biogeochemical cycling in catchments and result in related ecological and environmental problems, and that the studies on areal change are important for studying global change.