Based on probing the relationship of geological, geophysical and geochemical information of Guyuan basin to uranium mineralization in Guyuan basin, quantification of each ore-control factors in the basin is carried out by means of MORPAS platform. And 16 evidence layers such as fracture buffer, sub- volcanic rock buffer and magnetic anomaly are extracted and constructed through spatial analysis of the MORPAS system. The research area has been divided into 9562 units with 1 km× 1 km for each unit. U- ranium potential is calculated by evidence weight model and 3 class targets are located thus put forward the prospecting direction for further exploration of uranium ore in the basin.