The spatial-temporal variations of atmospheric water vapor in western Sichuan Province and its vicinity during the mid-and long-term earthquake preparation process are studied. The MS8.0 Wenchuan earthquake in 2008, the Songpan-Pingwu earthquake sequence in 1976 and the Yushu MS7.1 earthquake in 2010 are selected as cases of the study regions. The result shows the frequency of atmospheric water vapor anomalies will decrease at first, then increase quickly during the mid-and long-term process of strong earthquake. The atmospheric water vapor anomalies over epicentral region may be due to the opening-closing movement of pores and fractures in the rock layer before the earthquake, resulting in the migration of underground fluid and underground heat energy, and then causing the change of the surface temperature and surface latent heat flux.