Effects of D-Polymannuronic Sulfate on Serum Nitric Oxide Levels and Plasma Endothelin -1 and Angiotensin ⅡContents in Renovascular Hypertensive Rats (SeriesⅡ)
- 出版年：2001
- 作者：朱海波；耿美玉；管华诗
- 单位1：青岛海洋大学海洋药物与食品研究所
- 出生年：1966
- 学历：博士
- 职称：讲师
- 语种：英文
- 作者关键词：marine D-polymannuronic sulfate (DPS)；antihypertensive effect；angiotensin Ⅱ；endothelin-1；renovaseular hypertensive rats
- 起始页：179
- 总页数：6
- 经费资助：国家“九五”科技攻关项目（96-C02-0）资助
- 刊名：青岛海洋大学学报
- 是否内版：否
- 刊频：双月刊
- 创刊时间：1959
- 主办单位：青岛海洋大学
- 主编：文圣常
- 卷：31
- 期：2
- 核心期刊：中国自然科学核心期刊
摘要
The effects of D-polymannuronic sulfate (DPS) on the serum nitric oxide levels and plasma Endothelin-1 and Angiotensin Ⅱcontents were studied in renovascular hypertensive rats [two-kidney one clip，Goldbtatt(2-K1C)]．In the prophylactic experiment in which thee ffects of DPS given orally at doses of 12.50，25.00 and 50.00mg／kg once daily for five weeks simultaneously with the initiation of the establishment of renovascular hypertensive model were evaluated．Serum nitric oxide (NO)was determined with nitric oxide kit while plasma Angiotensin Ⅱ(AngⅡ) and Endothelin-1 (ET-1)were measured by radioimmunoassay．Captopril (14mg／kg)，an Angiotensin Ⅱ inhibitor，was served as a positive agent. The results showed that DPS could produce a dose-dependent effect on increased serum nitric oxide levels and decreased Endothelin-1 contents，whereas the inhibitory effect of DPS on plasma Angiotensin Ⅱcontents was not found in a dose-dependent manner. It implicates that the mechanisms underlying the antihypertensive effects of DPS might be associated with its actions on increasing the synthesis or release of NO and decreasing the production of AngⅡandET-1 in vivo.