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173pt; mso-spacerun: 'yes'">In the paper entitled 173pt; mso-spacerun: 'yes'">“173pt; mso-spacerun: 'yes'">Two independent real-time precursors of the 7.8 M earthquake in Ecuador based on 173pt; mso-spacerun: 'yes'">radioactive and geodetic processes 173pt; mso-spacerun: 'yes'">– 173pt; mso-spacerun: 'yes'">Powerful tools for an early warning system173pt; mso-spacerun: 'yes'">”173pt; mso-spacerun: 'yes'">, Toulkeridis et al. (2019) claim 173pt; mso-spacerun: 'yes'">that they found radiation and GPS signal anomalies before the April 16th 173pt; mso-spacerun: 'yes'">2016 Pedernales earthquake (Ecuador) 173pt; mso-spacerun: 'yes'">and that their 173pt; mso-spacerun: 'yes'">fifi173pt; mso-spacerun: 'yes'">ndings can be used to forecast earthquakes in the medium and short term in active continental 173pt; mso-spacerun: 'yes'">margins. Using an extended data set that overlaps Toulkeridis et al. (2019) study period, we 173pt; mso-spacerun: 'yes'">fifi173pt; mso-spacerun: 'yes'">nd: (1) the success 173pt; mso-spacerun: 'yes'">rate of predicting earthquakes using radiation anomalies is 2.5 %; (2) radiation anomalies, including the one 173pt; mso-spacerun: 'yes'">recorded during the hours before the M 7.8 earthquake, temporally correlate with local rainfall; (3) Toulkeridis 173pt; mso-spacerun: 'yes'">et al. (2019) GPS results are physically unrealistic and inconsistent with previously published GPS and InSAR 173pt; mso-spacerun: 'yes'">analysis; (4) there is no anomaly in the GPS time series before the earthquake. Therefore, Toulkeridis et al. 173pt; mso-spacerun: 'yes'">(2019) results are not reliable evidence of precursors to the M 7.8 earthquake in 2016 in Ecuador, and their 173pt; mso-spacerun: 'yes'">proposed method cannot be used to forecast earthquakes.