Renoprotective effects of berberine and its potential effect on the expression of β-arrestins and intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in streptozocin-diabetic nephropathy rats 小檗碱对STZ诱导的糖尿病肾病大鼠的保护作用及其对β-arrestins、ICAM-1和VCAM-1表达的影响

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• 作者：Li-Qin Tang ; Wei-Jian Ni ; Ming Cai ; Hai-Hua Ding ; Sheng Liu and Shan-Tang Zhang
• 刊名：Journal of Diabetes
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：8
• 期：5
• 页码：693-700
• 全文大小：502K
• ISSN：1753-0407

文摘

Berberine has been shown to exert protective effects against diabetic nephropathy (DN), but the mechanisms involved have not been fully characterized. The aim of the present study was to explore the effects of berberine on the expression of β-arrestins, intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in DN rat kidneys and investigate the underlying molecular mechanisms.