Variant of the clock circadian regulator (CLOCK) gene and related haplotypes are associated with the prevalence of type 2 diabetes in the Japanese population 在日本人群中昼夜节律时钟调节(CLOCK)基因变异以及相关的单倍型与2型糖尿病的患病率有关
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- 作者：Hirokazu Uemura ; Sakurako Katsuura-Kamano ; Miwa Yamaguchi ; Kokichi Arisawa ; Nobuyuki Hamajima ; Asahi Hishida ; Sayo Kawai ; Isao Oze ; Koichi Shinchi ; Naoyuki Takashima ; Sadao Suzuki ; Noriko Nakahata ; Haruo Mikami ; Keizo Ohnaka ; Nagato Kuriyama ; Michiaki Kubo ; Hideo Tanaka and for the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group
- 刊名：Journal of Diabetes
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：8
- 期：5
- 页码：667-676
- 全文大小：310K
- ISSN：1753-0407
文摘
Circadian rhythm disruptions can cause various health disorders. The present study evaluated associations between single nucleotide polymorphisms in the core circadian gene clock circadian regulator (CLOCK) and the prevalence of type 2 diabetes (T2D) in the Japanese population.