H2-Fueled ATP Synthesis on an Electrode: Mimicking Cellular Respiration

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• 作者：Dr. Ó ; scar Gutié ; rrez-Sanz ; Dr. Paolo Natale ; Dr. Ileana Má ; rquez ; Dr. Marta C. Marques ; Sonia Zacarias ; Dr. Marcos Pita ; Dr. In&#234 ; s A. C. Pereira ; Dr. Ivá ; n Ló ; pez-Montero ; Dr. Antonio L. De Lacey and Dr. Marisela Vé ; lez
• 刊名：Angewandte Chemie
• 出版年：2016
• 出版时间：May 17, 2016
• 年：2016
• 卷：128
• 期：21
• 页码：6324-6328
• 全文大小：1735K
• ISSN：1521-3757

文摘

ATP, the molecule used by living organisms to supply energy to many different metabolic processes, is synthesized mostly by the ATPase synthase using a proton or sodium gradient generated across a lipid membrane. We present evidence that a modified electrode surface integrating a NiFeSe hydrogenase and a F₁F₀-ATPase in a lipid membrane can couple the electrochemical oxidation of H₂ to the synthesis of ATP. This electrode-assisted conversion of H₂ gas into ATP could serve to generate this biochemical fuel locally when required in biomedical devices or enzymatic synthesis of valuable products.