Effect of the interaction between childhood abuse and rs1360780 of the FKBP5 gene on gray matter volume in a general population sample
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- 作者：Hans Jö ; rgen Grabe ; Katharina Wittfeld ; Sandra Van der Auwera ; Deborah Janowitz ; Katrin Hegenscheid ; Mohamad Habes ; Georg Homuth ; Sven Barnow ; Ulrich John ; Matthias Nauck ; Henry Vö ; lzke ; Henriette Meyer zu Schwabedissen ; Harald Jü ; rgen Freyberger and Norbert Hosten
- 关键词：major depression disorder ; stress-related disorders ; childhood abuse ; general population ; FKBP5 gene ; gene&ndash ; environment interaction ; CTQ ; MRI ; SPM8 ; VBM8
- 刊名：Human Brain Mapping
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：37
- 期：4
- 页码：1602-1613
- 全文大小：295K
- ISSN：1097-0193
文摘
The FKBP5 gene codes for a co-chaperone that regulates glucocorticoid receptor sensitivity and thereby impacts the reactivity of the hypothalamic–pituitary–adrenal (HPA)-axis. Evidence suggested that subjects exposed to childhood abuse and carrying the TT genotype of the FKBP5 gene single nucleotide polymorphism (SNP) rs1360780 have an increased susceptibility to stress-related disorders.