Back Cover: Characterization of a Cell-Penetrating Peptide with Potential Anticancer Activity (ChemMedChem 1/2017)

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• 作者：Anja Gronewold ; Mareike Horn ; Ivan Ranđelović ; Dr. Jó ; zsef Tó ; v&aacute ; ri ; Sergio Muñ ; oz V&aacute ; zquez ; Prof. Dr. Klaus Schom&auml ; cker and Prof. Dr. Ines Neundorf
• 刊名：ChemMedChem
• 出版年：2017
• 出版时间：January 5, 2017
• 年：2017
• 卷：12
• 期：1
• 页码：104
• 全文大小：932K
• ISSN：1860-7187

文摘

The back cover picture shows how the branched cell-penetrating peptide (CPP), namely (sC18)₂, effectively enters cancerous cells. Owing to its structural properties, different interactions between cancerous and noncancerous cells occur, leading to obvious different entry pathways. As a result, (sC18)₂ strongly affects cancerous cells and exhibits significant toxic activity to a wide range of different cancer cell types. Moreover, synergistic effects were obtained when combining the CPP with the cytostatic drug actinomycin D. More information can be found in the Full Paper by Ines Neundorf et al. on page 42 in Issue 1, 2017 (DOI:mdc.201600498" rel="references:https://doi.org/10.1002/cmdc.201600498">10.1002/cmdc.201600498).