Genomic data integration in chronic lymphocytic leukemia
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- 作者：Juan Luis Ferná ; ndez-Martí ; nez ; Enrique J. deAndré ; s-Galiana and Stephen T. Sonis
- 刊名：The Journal of Gene Medicine
- 出版年：2017
- 出版时间：January-February 2017
- 年：2017
- 卷：19
- 期：1-2
- 全文大小：1199K
- ISSN：1521-2254
文摘
B-cell chronic lymphocytic leukemia (CLL) is a heterogeneous disease and the most common adult leukemia in western countries. IgVH mutational status distinguishes two major types of CLL, each associated with a different prognosis and survival. Sequencing identified NOTCH1 and SF3B1 as the two main recurrent mutations. We described a novel method to clarify how these mutations affect gene expression by finding small-scale signatures that predict the IgVH, NOTCH1 and SF3B1 mutations. We subsequently defined the biological pathways and correlation networks involved in disease development, with the potential goal of identifying new drugable targets.