Inhibition of the NorA efflux pump of Staphylococcus aureus by synthetic riparins

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• 作者：L.M. Costa ; E.V. de Macedo ; F.A.A. Oliveira ; J.H.L. Ferreira ; S.J.C. Gutierrez ; W.J. Pel&aacute ; ez ; F.C.A. Lima ; J.P. de Siqueira Jú ; nior ; H.D.M. Coutinho ; G.W. Kaatz ; R.M. de Freitas and H.M. Barreto
• 刊名：Journal of Applied Microbiology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：121
• 期：5
• 页码：1312-1322
• 全文大小：1015K
• ISSN：1365-2672

文摘

The goal of this study was to increase knowledge about the antimicrobial activity of some synthetic Riparin-derived compounds, alone or in combination with fluoroquinolone antibiotics, against a strain of Staphylococcus aureus resistant to fluoroquinolone by way of overexpression of the NorA efflux pump.