Synthesis of a Novel Tri-enaminone as Building Block for Polyaza-heterocycles

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• 作者：Thoraya A. Farghaly ; Magda A. Abdallah and Mohamed R. Abdel Aziz
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：699-705
• 全文大小：868K
• ISSN：1943-5193

文摘

The new tri-enaminone, namely, r="urn://wiley-online-library/content/render" xmlns:mml="http://www.w3.org/1998/Math/MathML" id="jhet2644-eo-0015">rm3">3,4-bis(3-dimethylamino-2-propenoyl)-1-[4-(3-dimethylamino-2-propenoyl)phenyl]-5-methyl-1H-pyrazole was prepared and used as building block for synthesis of novel polyaza-heterocycles. The latter compounds were obtained via an efficient rm4">one-pot reaction of the tri-enaminone with 1,3-dipoles and various electrophilic and rm4">nucleophilic reagents. The structures of the new products were confirmed based on elemental and spectral analyses. Also, alternative synthetic methods were carried out wherever possible as further evidence for some of the newly synthesized products.