Inside Back Cover: Supramolecular Self-Assembly of Histidine-Capped-Dialkoxy-Anthracene: A Visible-Light-Triggered Platform for Facile siRNA Delivery (Chem. Eur. J. 39/2016)
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- 作者：Dr. Sachin P. Patil ; Dr. Basem A. Moosa ; Shahad Alsaiari ; Kholod Alamoudi ; Dr. Aws Alshamsan ; Dr. Abdulaziz AlMalik ; Dr. Karim Adil ; Prof. Mohamed Eddaoudi and Prof. Niveen M. Khashab
- 刊名：Chemistry - A European Journal
- 出版年：2016
- 出版时间：September 19, 2016
- 年：2016
- 卷：22
- 期：39
- 页码：14067
- 全文大小：1350K
- ISSN：1521-3765
文摘
A 9,10-dialkoxy-substituted anthracene linker has been designed and synthesized and used as a light-responsive platform to deliver siRNA. The histidine-substituted linker self-assembled in the presence of RNA forming a smart and biocompatible delivery capsule. This process is mediated by singlet oxygen, which cleaves the dialkoxyanthracene linker leading to the knocking down of Bcl-2 gene expression with up to 90% in live cells. More information can be found in the Communication by N. M. Khashab et al. on page 13789 ff.