Transformation of 1,2,3-Thiadiazolyl Hydrazones as Method for Preparation of 1,2,3-Triazolo[5,1-b][1,3,4]thiadiazines

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• 作者：Tatiana A. Kalinina ; Olga A. Bystrykh ; Tatiana V. Glukhareva and Yuri Yu. Morzherin
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：137-146
• 全文大小：828K
• ISSN：1943-5193

文摘

The transformation of 1,2,3-thiadiazolyl hydrazones of aldehydes and ketones including Dimroth rearrangement giving 1-alkylidenamino-5-mercapto-1,2,3-triazoles, alkylation of mercapto group of these heterocyclic compounds by α-bromoacetophenones and cyclization giving 6,7-dihydro-5H-[1,2,3]triazolo[5,1-b][1,3,4]thiadizines have been investigated. It was shown that the reaction for hydrazones of acetophenones and benzoaldehydes is diastereoselective. Triazolothiadiazine spiro derivatives were prepared with transformation of hydrazones of cyclic ketones.