Underlying undiagnosed inherited marrow failure syndromes among children with cancer

详细信息    查看全文

• 作者：Fahad Alabbas ; Sheila Weitzman ; Ronald Grant ; Eric Bouffet ; David Malkin ; Oussama Abla and Yigal Dror
• 刊名：Pediatric Blood & Cancer
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：64
• 期：2
• 页码：302-305
• 全文大小：162K
• ISSN：1545-5017

文摘

To study the prevalence of pediatric cancer patients who have underlying inherited bone marrow failure syndrome (IBMFS), we retrospectively reviewed the medical records of newly diagnosed pediatric cancer patients at The Hospital for Sick Children from June 2009 to May 2010, focusing on clinical, laboratory, and treatment-related findings which may indicate underlying IBMFS. We found five (1.8%) patients out of 276 who had two or more findings suggestive of IBMFS. We conclude that a small fraction of patients with cancer have clinical features that indicate investigations to rule out underlying IBMFSs. A prospective study is needed to determine their prevalence.