A Randomized Trial Evaluating Whether Topiramate Aids Smoking Cessation and Prevents Alcohol Relapse in Recovering Alcohol-Dependent Men
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- 作者：Robert M. Anthenelli ; Jaimee L. Heffner ; Esther Wong ; Jessie Tibbs ; Katie Russell ; Melodie Isgro ; Elizabeth Dinh ; Chris Wehrle ; Matthew J. Worley and Neal Doran
- 刊名：Alcoholism: Clinical and Experimental Research
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：41
- 期：1
- 页码：197-206
- 全文大小：827K
- ISSN：1530-0277
文摘
Alcohol and nicotine dependence frequently co-occur, and quitting smoking might enhance long-term alcohol abstinence. Topiramate appears to help non-alcohol-dependent individuals quit smoking, and our pilot work suggested efficacy only in men. It also prevents relapse to alcohol in recently detoxified alcoholics. We evaluated topiramate in abstinent alcohol-dependent men to assess whether this medication (i) promotes smoking cessation and (ii) prevents alcohol and other drug relapse in the context of smoking cessation treatment.