Au^III-Catalyzed Formation of α-Halomethyl Ketones from Terminal Alkynes

详细信息    查看全文

• 作者：Yalan Xing ; Ming Zhang ; Sarah Ciccarelli ; John Lee and Bryant Catano
• 刊名：European Journal of Organic Chemistry
• 出版年：2017
• 出版时间：January 26, 2017
• 年：2017
• 卷：2017
• 期：4
• 页码：781-785
• 全文大小：992K
• ISSN：1099-0690

文摘

A Au^III-catalyzed synthesis of α-halomethyl ketones from terminal alkynes was developed. This approach features excellent functional group compatibility and good yields for both aromatic and aliphatic terminal alkynes. The resulting α-halomethyl ketones were used to prepare heterocyclic indolizine structures. The plausible mechanism of the one-pot reaction is proposed.