Role of hypoxia-related proteins in invasion of ameloblastoma cells: crosstalk between NOTCH1, hypoxia-inducible factor 1, a disintegrin and metalloproteinase 12, and heparin-binding epidermal growth factor
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- 作者：Natacha Malu Miranda da Costa ; Amanda Dalla Vechia Fialho ; Carolina Carmine Proietti ; Maria Sueli da Silva Kataoka ; Ruy Gastaldoni Jaeger ; Sé ; rgio Melo de Alves-Jú ; nior and Joã ; o de Jesus Viana Pinheiro
- 刊名：Histopathology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：69
- 期：1
- 页码：99-106
- 全文大小：1566K
- ISSN：1365-2559
文摘
Ameloblastoma AME is a benign tumour characterized by local invasiveness, high recurrence rates, and diverse histological patterns. The oxygen concentration is reduced in specific areas of the tumour microenvironment, which leads to intratumoral hypoxia. Crosstalk between NOTCH1, a disintegrin and metalloproteinase 12 (ADAM-12), hypoxia-inducible factor 1α (HIF-1α) and heparin-binding epidermal growth factor (HB-EGF) under hypoxic conditions has been implicated in invadopodia formation, tumour invasiveness, and metastasis development. The aim of this study was to analyse the expression of these proteins, in order to further elucidate the mechanisms underlying AME invasiveness.