Synthesis of N-Arylcarbazoles by Palladium-Catalyzed Direct C-H Arylation of 2-(Diarylamino)phenyl Triflates

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• 作者：Koji Uwa ; Ya-Yi Tseng and Ken Kamikawa
• 刊名：European Journal of Organic Chemistry
• 出版年：2017
• 出版时间：January 26, 2017
• 年：2017
• 卷：2017
• 期：4
• 页码：892-895
• 全文大小：605K
• ISSN：1099-0690

文摘

The palladium-catalyzed direct arylation of a series of 2-(diarylamino)phenyl triflates was examined. The triflates were first synthesized in moderate to good yields through the CuI-catalyzed aryl amination of aminophenol and aryl iodides, followed by triflation of the resulting triarylphenols. The thus-obtained 2-(diarylamino)phenyl triflates were subjected to direct C–H arylation under Pd catalysis to furnish the corresponding N-arylcarbazoles in excellent yields if Josiphos was used as the supporting ligand.