Impact of statin therapy on plasma leptin concentrations: a systematic review and meta-analysis of randomized placebo-controlled trials

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• 作者：Amirhossein Sahebkar ; Renato Giua and Claudio Pedone
• 刊名：British Journal of Clinical Pharmacology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：82
• 期：6
• 页码：1674-1684
• 全文大小：1087K
• ISSN：1365-2125

文摘

The effects of statins on insulin sensitivity, metabolic homeostasis and adipokines in humans are controversial. Several studies have investigated the impact of statin therapy on plasma leptin concentrations but the results have been inconsistent. The aim of the present study was to conduct a systematic review and meta-analysis of available evidence to calculate the effect size of statin therapy in changing serum leptin concentrations.