Ventricular repolarization time, location of pacing stimulus and current pulse amplitude conspire to determine arrhythmogenicity in mice
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- 作者：T. Speerschneider ; S. Grubb ; S. P. Olesen ; K. Calloe and M. B. Thomsen
- 刊名：Acta Physiologica
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：219
- 期：3
- 页码：660-668
- 全文大小：1005K
- ISSN：1748-1716
文摘
In this study, we investigate the impact of altered action potential durations (APD) on ventricular repolarization time and proarrhythmia in mice with and without genetic deletion of the K+-channel-interacting protein 2 (KChIP2−/− and WT respectively). Moreover, we examine the interrelationship between the dispersion of repolarization time and current pulse amplitude in provoking ventricular arrhythmia.