Axon density and axon orientation dispersion in children born preterm

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• 作者：Claire E. Kelly ; Deanne K. Thompson ; Jian Chen ; Alexander Leemans ; Christopher L. Adamson ; Terrie E. Inder ; Jeanie L.Y. Cheong ; Lex W. Doyle and Peter J. Anderson
• 刊名：Human Brain Mapping
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：37
• 期：9
• 页码：3080-3102
• 全文大小：849K
• ISSN：1097-0193

文摘

Very preterm birth (VPT, <32 weeks' gestation) is associated with altered white matter fractional anisotropy (FA), the biological basis of which is uncertain but may relate to changes in axon density and/or dispersion, which can be measured using Neurite Orientation Dispersion and Density Imaging (NODDI). This study aimed to compare whole brain white matter FA, axon dispersion, and axon density between VPT children and controls (born ≥37 weeks' gestation), and to investigate associations with perinatal factors and neurodevelopmental outcomes.