Embryonic stem cells markers Oct4 and Nanog correlate with perineural invasion in human salivary gland mucoepidermoid carcinoma
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- 作者：Maria Fernanda Setú ; bal Destro Rodrigues ; Bruno Tavares Sedassari ; Carina Magalhã ; es Esteves ; Nathá ; lia Paiva de Andrade ; Albina Altemani ; Suzana Cantanhede Orsini Machado de Sousa and Fabio Daumas Nunes
- 刊名：Journal of Oral Pathology & Medicine
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：46
- 期：2
- 页码：112-120
- 全文大小：1405K
- ISSN：1600-0714
文摘
Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy and is successfully treated by surgery and radiation. However, some patients have recurrent tumours and in these cases, few treatments options are available. Cancer stem cells (CSC) have been observed and isolated from different solid tumours based on the expression of stem cell markers. These cells are associated with tumour initiation, progression as well as treatment resistance. In this study, the expression of stem cell markers CD44, Bmi1, Oct4 and Nanog was evaluated in non-neoplastic salivary tissue and in MEC.