A Micropatterned Human Pluripotent Stem Cell-Based Ventricular Cardiac Anisotropic Sheet for Visualizing Drug-Induced Arrhythmogenicity
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- 作者：Angie M. Y. Shum ; Hui Che ; Andy On-Tik Wong ; Chenzi Zhang ; Hongkai Wu ; Camie W. Y. Chan ; Kevin Costa ; Michelle Khine ; Chi-Wing Kong and Ronald A. Li
- 刊名：Advanced Materials
- 出版年：2017
- 出版时间：January 4, 2017
- 年：2017
- 卷：29
- 期：1
- 全文大小：1318K
- ISSN：1521-4095
文摘
A novel cardiomimetic biohybrid material, termed as the human ventricular cardiac anisotropic sheet (hvCAS) is reported. Well-characterized human pluripotent stem-cell-derived ventricular cardiomyocytes are strategically aligned to reproduce key electrophysiological features of native human ventricle, which, along with specific selection criteria, allows for a direct visualization of arrhythmic spiral re-entry and represents a revolutionary tool to assess preclinical drug-induced arrhythmogenicity.