Cold physical plasma selects for specific T helper cell subsets with distinct cells surface markers in a caspase-dependent and NF-κB-independent manner

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• 作者：Sander Bekeschus ; Katrin R&ouml ; dder ; Anke Schmidt ; Matthias B. Stope ; Thomas von Woedtke ; Vandana Miller ; Alexander Fridman ; Klaus-Dieter Weltmann ; Kai Masur ; Hans-Robert Metelmann ; Kristian Wende and Sybille Hasse
• 刊名：Plasma Processes and Polymers
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：13
• 期：12
• 页码：1144-1150
• 全文大小：833K
• ISSN：1612-8869

文摘

Exposure to cold physical plasma has been proposed to be of therapeutical value in oncology via the generation of a number of biologically relevant redox-active molecules. Cancer cells can be recognized and eliminated by cells of the immune system, and accordingly many tumors are populated with these cells, among them T helper cells (T_H cells). These lymphocyte population is crucial for effector immune responses against tumor antigens, in response to immunogenic cell death in malignant cells. However, a number of T_H populations exists, each having distinct phenotypical features. Using a cold atmospheric pressure argon plasma jet, its redox activity was tested in different T_H cell subpopulations to better understand the immunological consequences of potential antitumor plasma treatments in vivo.