Regional hypoplasia of somatosensory cortex in growth-retarded mice (grt/grt)

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• 作者：Kazuhiko Sawada ; Shigeyoshi Saito ; Akari Sugasawa ; Chika Sato ; Junya Aoyama ; Naoko Ohara ; Miwa Horiuchi-Hirose and Tetsuya Kobayashi
• 刊名：Congenital Anomalies
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：56
• 期：4
• 页码：180-183
• 全文大小：950K
• ISSN：1741-4520

文摘

Growth-retarded mouse (grt/grt) is a spontaneous mutant that is known as an animal model for primary congenital hypothyroidism caused by resistance to TSH signaling. The regional pattern of cerebral cortical hypoplasia was characterized in grt/grt mice. Ex vivo computed tomography (CT)-based volumetry was examined in four regions of the cerebral cortex, i.e., prefrontal, frontal, parietal and occipito-temporal regions, which were demarcated by structural landmarks on coronal CT images. A region-specific reduced volume of the parietal cortical region covering most of the somatosensory cortex was noted in grt/grt mice rather than in both heterozygous (grt/+) and wild-type (+/+) mice. We concluded that the cortical hypoplasia in grt/grt was seen in identical cortical regions corresponding to human congenital hypothyroidism.