Effects of NRG1 genotypes on orbitofrontal sulcogyral patterns in Japanese patients diagnosed with schizophrenia

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• 作者：Asuka Yoshimi ; Akira Suda ; Fumi Hayano ; Motoaki Nakamura ; Kumi Aoyama-Uehara ; Jun Konishi ; Takeshi Asami ; Ikuko Kishida ; Chiaki Kawanishi ; Tomio Inoue ; Robert W. McCarley ; Martha E. Shenton and Yoshio Hirayasu
• 刊名：Psychiatry and Clinical Neurosciences
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：70
• 期：7
• 页码：261-268
• 全文大小：250K
• ISSN：1440-1819

文摘

Numerous reports have described differences in the distribution of orbitofrontal cortex (OFC) sulcogyral patterns between patients with schizophrenia (SZ patients) and healthy controls (HC). Alterations in OFC morphology are also observed in those at high risk for developing SZ and in first-episode SZ, suggesting that genetic associations may be extant in determining OFC sulcogyral patterns. We investigated the association between single nucleotide polymorphisms (SNP) in NRG1 and OFC sulcogyral patterns.