Arterial Stiffness in Treated Hypertensive Patients With White-Coat Hypertension

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• 作者：Jessica Barochiner ; Lucas S. Aparicio ; José ; Alfie ; Margarita S. Morales ; Paula E. Cuffaro ; Marcelo A. Rada ; Marcos J. Marin ; Carlos R. Galarza and Gabriel D. Waisman
• 刊名：The Journal of Clinical Hypertension
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：19
• 期：1
• 页码：6-10
• 全文大小：139K
• ISSN：1751-7176

文摘

Arterial stiffness, assessed through pulse wave velocity (PWV), independently predicts cardiovascular outcomes. In untreated persons, white-coat hypertension (WCH) has been related to arterial stiffness, but data in treated patients with WCH are scarce. The authors aimed to determine a possible association between WCH and arterial stiffness in this population. Adult treated hypertensive patients underwent home blood pressure monitoring and PWV assessment. Variables associated with PWV in univariable analyses were entered into a multivariable linear regression model. The study included 121 patients, 33.9% men, median age 67.9 (interquartile range 18.4) years, 5.8% with diabetes, and 3.3% with a history of cardiovascular or cerebrovascular disease. In multivariable analysis, WCH in treated hypertensive patients remained a determinant of PWV: β=1.1 (95% confidence interval, 0.1–2.1 [P=.037]; adjusted R² 0.49). In conclusion, WCH is independently associated with arterial stiffness in treated hypertensive patients. Whether this high-risk association is offset by antihypertensive treatment should be further investigated.