Fecal neutrophil gelatinase-associated lipocalin as a biomarker for inflammatory bowel disease

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• 作者：Silje Thorsvik ; Jan Kristian Dam&aring ; s ; Atle vB Granlund ; Trude Helen Flo ; K&aring ; re Bergh ; Ann Elisabet Ø ; stvik and Arne Kristian Sandvik
• 刊名：Journal of Gastroenterology and Hepatology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：32
• 期：1
• 页码：128-135
• 全文大小：919K
• ISSN：1440-1746

文摘

Accurate, noninvasive biomarkers are needed to diagnose and monitor inflammatory bowel disease (IBD). Neutrophil gelatinase-associated lipocalin (NGAL), also known as lipocalin 2, is expressed in inflamed colonic epithelium and neutrophilic granulocytes. This study explores its properties as a biomarker in feces and plasma and, for the first time, compares fecal NGAL systematically with the existing fecal biomarker calprotectin.