Genetics of psychosis of Alzheimer disease

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• 作者：Chintan Shah ; Mary Ann A. DeMichele-Sweet and Robert A. Sweet
• 刊名：American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：174
• 期：1
• 页码：27-35
• 全文大小：132K
• ISSN：1552-485X

文摘

Psychotic symptoms, comprised of delusions and hallucinations, occur in about half of individuals with Alzheimer disease (AD with psychosis, AD+P). These individuals have greater agitation, aggression, depression, functional impairment, and mortality than individuals without psychosis (AD−P). Although the exact etiopathogenesis of AD+P is unclear, the rapidly developing field of genomics continues to expand our understanding of this disease. Several independent studies have demonstrated familial aggregation and heritability of AD+P. Linkage studies have been suggestive of loci on several chromosomes associated with AD+P. Association studies examining apolipoprotein E gene, the best established genetic risk factor for late-onset AD, did not find any significant association of this gene with AD+P. Other candidate gene studies focusing on monoamine neurotransmitter systems have yielded equivocal results. A genome-wide association study and studies examining copy number variations recently have detected suggestive associations, but have been underpowered. Approaches to increase sizes of AD+P samples for genome wide association studies are discussed.