Novel 6-(1,2,3-tri
azol-4-yl)-5-[(2-(thi
azol-2-yl)hydr
azono)methyl]imid
azo[2,1-
b]thi
azoles
,
, and
were prepared by reaction of thiosemicarb
azone
with either hydr
azonoyl chloride
, phenacylbromides
or
2-bromo-1-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)ethanone respectively. The new products were tested for their antimicrobial activities using 96-well micro-plate assay, and compound
showed excellent antibacterial activities compared with Vancomycine (reference drugs), while compounds
and
exhibited good results against yeast. The minimum inhibitory concentration (MIC) was determined, and compound
showed the lowest MIC against Gram positive bacteria while compound
showed the lowest MIC against yeast.