In Vivo Therapeutic Success of MicroRNA-155 Antagomir in a Mouse Model of Lupus Alveolar Hemorrhage
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- 作者：Shiyu Zhou ; Yan Wang ; Yao Meng ; Chunyuan Xiao ; Zheng Liu ; Philip Brohawn ; Brandon W. Higgs ; Bahija Jallal ; Qian Jia ; Bo Qu ; Xinfang Huang ; Yuanjia Tang ; Yihong Yao ; John B. Harley and Nan Shen
- 刊名：Arthritis & Rheumatism
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：68
- 期：4
- 页码：953-964
- 全文大小：679K
- ISSN：1529-0131
文摘
Diffuse alveolar hemorrhage (DAH) is a rare but life-threatening complication of systemic lupus erythematosus (SLE). Pristane-treated B6 mice develop severe DAH within 2 weeks of treatment. MicroRNA-155 (miR-155) is a pleiotropic microRNA that plays a crucial role in the regulation of immune responses. Recent studies have revealed a pathogenic role of miR-155 in various autoimmune disorders. The purpose of this study was to examine the role of miR-155 in the development of DAH in pristane-induced lupus using miR-155–knockout (miR-155−/−) mice and miR-155 antagomir to silence miR-155.