Weight loss induced by bariatric surgery restores adipose tissue PNPLA3 expression

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• 作者：Verena Wieser ; Timon E. Adolph ; Barbara Enrich ; Patrizia Moser ; Alexander R. Moschen and Herbert Tilg
• 刊名：Liver International
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：37
• 期：2
• 页码：299-306
• 全文大小：659K
• ISSN：1478-3231

文摘

Obesity and its related co-morbidities such as non-alcoholic fatty liver disease (NAFLD) are increasing dramatically worldwide. The genetic variation in Patatin-like phospholipase domain-containing protein 3 (PNPLA3), which is also called adiponutrin (ADPN), in residue 148 (I148M, rs738409) has been associated with NAFLD. However, the regulation and function of PNPLA3 in metabolic diseases remains unclear. Laparoscopic gastric banding (LAGB) of severely obese patients reduces body weight, liver and adipose tissue inflammation. In this study, we investigated whether weight loss induced by LAGB affected PNPLA3 expression in hepatic and adipose tissue.