Bruton's Tyrosine Kinase Deficiency Inhibits Autoimmune Arthritis in Mice but Fails to Block Immune Complex-Mediated Inflammatory Arthritis
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- 作者：Lindsay E. Nyhoff ; Bridgette L. Barron ; Elizabeth M. Johnson ; Rachel H. Bonami ; Damian Maseda ; Benjamin A. Fensterheim ; Wei Han ; Timothy S. Blackwell ; Leslie J. Crofford and Peggy L. Kendall
- 刊名：Arthritis & Rheumatism
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：68
- 期：8
- 页码：1856-1868
- 全文大小：943K
- ISSN：1529-0131
文摘
Bruton's tyrosine kinase (BTK) is a B cell signaling protein that also contributes to innate immunity. BTK inhibitors prevent autoimmune arthritis but have off-target effects, and the mechanisms of protection remain unknown. We undertook these studies using genetic deletion to investigate the role of BTK in adaptive and innate immune responses that drive inflammatory arthritis.