Novel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF-C/VEGFR-3 signalling pathway

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• 作者：M Garcí ; a-Caballero ; S Blacher ; J Paupert ; A R Quesada ; M A Medina and A Noë ; l
• 刊名：British Journal of Pharmacology
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：173
• 期：12
• 页码：1966-1987
• 全文大小：9468K
• ISSN：1476-5381

文摘

Lymphangiogenesis is an important biological process associated with the pathogenesis of several diseases, including metastatic dissemination, graft rejection, lymphoedema and other inflammatory disorders. The development of new drugs that block lymphangiogenesis has become a promising therapeutic strategy. In this study, we investigated the ability of toluquinol, a 2-methyl-hydroquinone isolated from the culture broth of the marine fungus Penicillium sp. HL-85-ALS5-R004, to inhibit lymphangiogenesis in vitro, ex vivo and in vivo.