Pharmacokinetic model of florfenicol in turbot (Scophthalmus maximus): establishment of optimal dosage and administration in medicated feed

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• 作者：V-R de Ocenda ; S Almeida-Prieto ; A Luzardo-Á ; lvarez ; J L Barja ; F J Otero-Espinar and J Blanco-Mé ; ndez
• 刊名：Journal of Fish Diseases
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：40
• 期：3
• 页码：411-424
• 全文大小：480K
• ISSN：1365-2761

文摘

The pharmacokinetics of florfenicol (FF) in turbot (Scophthalmus maximus) was studied after single intravenous (10 mg kg⁻¹) and oral (100 mg kg⁻¹) administration. The plasma concentration–time data of florfenicol were described by an open one-compartment model. The elimination half-life (t_1/2) was estimated to be 21.0 h, and the total body clearance, Cl, was determined as 0.028 L kg h⁻¹. The apparent volume distribution (V_d) was calculated to be 0.86 L kg⁻¹ and the mean residence time (MRT_iv) was 30.2 h. Following oral administration, the maximum plasma concentration (C_max) of 55.4 μg mL⁻¹ was reached at 12 h (T_max). The absorption constant (k_a) was 0.158 h⁻¹. The bioavailability was estimated to be 57.1%. The low bioavailability observed at higher doses was explained by the saturation of the mechanisms of absorption. The drug absorption process was limited by its inherent low solubility, which limited the amount of available FF absorbed in the gastrointestinal tract.