Complexes for Photodynamic Therapy In their Communication on
page 234 ff., J. A. Weinstein, H. E. Bryant et al. present two low-mo
lecular-weight, long-lived and photo-stab
le iridium comp
lexes of the [Ir(N C)
2(N N)]
+ family which have high two-photon absorption and localise to mitochondria and lysosomal structures. Both are efficient photosensitizers (PS) under 1-photon irradiation resulting in apoptotic death in cancer cell lines at low light doses, low concentrations, and high photo-indices. Comp
lex
1 also displays high PS activity under NIR two-photon excitation, which along with its photo-stability indicates potential future clinical application.